New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase

B Bonnet, D Soullez, E Davioud-Charvet…

Index: Bonnet, Beatrice; Soullez, David; Davioud-Charvet, Elisabeth; Landry, Valerie; Horvath, Dragos; Sergheraert, Christian Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 7 p. 1249 - 1256

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Citation Number: 47

Abstract

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC50 values were assessed between 0.3 and 3 μM. Compound 32 (Ki= 0.4 μM) is the most potent TR inhibitor described so far.