C1??Symmetric Sulfoximines as Ligands in Copper??Catalyzed Asymmetric Mukaiyama??Type Aldol Reactions

M Langner, C Bolm

Index: Langner, Martin; Bolm, Carsten Angewandte Chemie - International Edition, 2004 , vol. 43, # 44 p. 5984 - 5987

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Citation Number: 99

Abstract

Since the report of the discovery of sulfoximines by Whitehead and Bentley in 1952,[1] they have found numerous applications in organic synthesis.[2] For example, they have been used as building blocks in bioactive molecules [3] and pseudopeptides,[4] chiral auxiliaries for asymmetric synthesis,[5] and ligands for enantioselective metal catalysis.[6] In the latter context we and others have prepared sulfoximines, such as 1 and 2, which lead to ...