Bulletin of the Chemical Society of Japan

Synthesis and Conformational Studies on 3-. OMICRON.-Tolylhydantoins by NMR and Molecular Modeling: Dipole-. PI. Attractions in Peptides and Proteins.

SH Park, AK Bose

Index: Park, Sang Hyun; Bose, Ajay K. Bulletin of the Chemical Society of Japan, 2001 , vol. 74, # 10 p. 1917 - 1925

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Citation Number: 3

Abstract

5-Pentafluorobenzyl-3-o-tolylhydantoin (2) was synthesized for reducing this π-electron density, and NMR studies have shown that we have succeeded in changing the conformation of 2 into an extended system instead of the folded conformation for the non- fluorinated compound, 5-benzyl-3-o-tolylhydantoin (1). Molecular modeling has also confirmed the extended structure for 2. An approach has been found for possibly ...