Organic letters

Efficient synthesis of 2-(trifluoromethyl) nicotinic acid derivatives from simple fluorinated precursors

LE Kiss, HS Ferreira, DA Learmonth

Index: Kiss, Laszlo E.; Ferreira, Humberto S.; Learmonth, David A. Organic Letters, 2008 , vol. 10, # 9 p. 1835 - 1837

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Citation Number: 24

Abstract

Novel routes to 2-trifluoromethyl-nicotinic acid derivatives have been developed involving synthesis of the pyridine ring. These pyridyl compounds serve as key intermediates in the manufacture of the recently discovered COMT inhibitor, 3-(5-(3, 4-dihydroxy-5-nitrophenyl)- 1, 2, 4-oxadiazol-3-yl)-2-(trifluoromethyl) pyridine 1-oxide.