Tetrahedron letters

Synthesis of bis (pyrrol-2-yl) arenes by Pd-catalyzed cross coupling

J Setsune, M Toda, K Watanabe, PK Panda…

Index: Setsune, Jun-ichiro; Toda, Masayuki; Watanabe, Keigo; Panda, Pradeepta K.; Yoshida, Takafumi Tetrahedron Letters, 2006 , vol. 47, # 43 p. 7541 - 7544

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Citation Number: 29

Abstract

2-Borylpyrrole was prepared from 2-iodopyrrole almost quantitatively and then reacted with dihaloarenes under typical reaction conditions of Suzuki–Miyaura cross coupling to give bis (pyrrol-2-yl) arenes in good yields, while the cross coupling reaction of 2-iodopyrrole with 1, 4-phenylenebisboronic acid was susceptible to oxidative self-coupling to produce 4, 4′-bis (pyrrol-2-yl) biphenyl as a byproduct. These bis (pyrrol-2-yl) arenes showed strong ...