Design, Synthesis, and Evaluation of 3??Aryl??4??pyrrolyl??maleimides as Glycogen Synthase Kinase??3β Inhibitors

…, JY Cao, L Xu, YJ Li, L Han, JR Gao, YZ Hu…

Index: Ye, Qing; Li, Meng; Zhou, Yu-Bo; Cao, Jia-Yu; Xu, Lei; Li, Yu-Jin; Han, Liang; Gao, Jian-Rong; Hu, Yong-Zhou; Li, Jia Archiv der Pharmazie, 2013 , vol. 346, # 5 p. 349 - 358

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Citation Number: 5

Abstract

Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine protein kinase that was first identified in the late 1970s as a consequence of its phosphorylation activity toward glycogen synthase (GS), the rate limiting enzyme of glycogen biosynthesis 1, 2. Today, it is known that GSK-3 plays an important role in various cellular and physiological events, such as the Wnt signaling pathway 3, insulin signal transduction 4, cell survival, response to DNA damage 5, ...