Photoredox Catalysis: A Mild, Operationally Simple Approach to the Synthesis of α??Trifluoromethyl Carbonyl Compounds
…, DA Nagib, DWC MacMillan
Index: Pham, Phong V.; Nagib, David A.; MacMillan, David W. C. Angewandte Chemie - International Edition, 2011 , vol. 50, # 40 p. 9232 - 9232
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Citation Number: 239
Abstract
The unique physical and chemical advantages conferred by the CÀF bond have led to the broad exploitation of this motif throughout the pharmaceutical,[1] materials,[2] and agrochemical [3] sectors. In drug design, for instance, incorporation of polyfluorinated alkyl groups, such as CF3 moieties, can profoundly impact the activity, metabolic stability, lipophilicity, and bioavailability of lead compounds.[1, 4] Not surprisingly, the development ...
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