Probing the proposed phenyl-A region of the sigma-1 receptor

SY Ablordeppey, JB Fischer, H Law…

Index: Ablordeppey, Seth Y; Fischer, James B; Law; Glennon, Richard A Bioorganic and medicinal chemistry, 2002 , vol. 10, # 8 p. 2759 - 2765

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Citation Number: 62

Abstract

The proposed phenyl-A region of sigma (σ) receptors accommodates several structural features. In this study we explored the possibility that appropriate structural features located at the phenyl-A region of σ receptor sites could lead to more potent and selective agents for the sigma receptor subtypes. By keeping the phenyl-B substituent as the optimum ω- phenylpentyl moiety, and varying substituents in the phenyl-A region, we have observed ...