Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework

GAM Giardina, HM Sarau, C Farina…

Index: Journal of Medicinal Chemistry, , vol. 40, # 12 p. 1794 - 1807

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Citation Number: 80

Abstract

... Journal of Medicinal Chemistry. ... Almost all the major pharmaceutical companies dedicated efforts to the identification of non-peptide antagonists selective for the three neurokinin receptors (NK-1, NK-2, and NK-3). These receptors, widely distributed in both the central nervous ...