Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine

…, SM Opalka, BS Campbell, BF Gupton…

Index: Longstreet, Ashley R.; Opalka, Suzanne M.; Campbell, Brian S.; Gupton, B. Frank; McQuade, D. Tyler Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 2570 - 2578

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Citation Number: 7

Abstract

Abstract 2-Chloro-3-amino-4-picoline (CAPIC) is a strategic building block for the preparation of nevirapine, a widely-prescribed non-nucleosidic reverse transcriptase inhibitor for the treatment of HIV-infected patients. A continuous synthesis to the bromo derivative of a CAPIC intermediate, 2-bromo-4-methylnicotinonitrile, that terminates in a dead-end crystallization is described. The route uses inexpensive, acyclic commodity- ...