Degradation kinetics and mechanism of N6??[(dimethylamino) methylene] mitomycin C in aqueous solutions

…, WP Coppola, WH Johns, JB Bogardus…

Index: Chen; Coppola; Johns; Bogardus; Lipper Journal of Pharmaceutical Sciences, 1986 , vol. 75, # 2 p. 208 - 210

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Citation Number: 4

Abstract

Abstract The degradation of N 6-[(dimethylamino) methylene] mitomycin C, a semisynthetic analogue of mitomycin C, was studied in aqueous solution. The compound degraded rapidly and followed pseudo-first-order kinetics in both acidic (pH< 5) and basic pH≥ 9) media. In the near-neutral pH region, however, biphasic kinetics were observed. At the pH of maximum stability (6.5), 10% activity was lost after 6 h at 22 C. Citrate and phosphate ...