The Journal of Organic Chemistry

Solvolysis of isothiazole analogs of cumyl chloride. Determination of the brown electrophilic substituent constants for isothiazole derivatives

DS Noyce, BB Sandel

Index: Noyce,D.S.; Sandel,B.B. Journal of Organic Chemistry, 1975 , vol. 40, p. 3381 - 3383

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Citation Number: 10

Abstract

Rates of solvolysis in 80% ethanol have been determined for 2-(3-isothiazolyl)-2- chloropropane, 2-(4-isothiazolyl)-2-chloropropane, and 2-(5-isothiazolyl)-2-chloropropane. From these rates and the rates of solvolysis of cumyl chlorides bearing electron-withdrawing substituents u+ values appropriate for the replacement of the benzene ring by an isothiazolyl moiety have been determined.