Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV 1.5 blockers

J Lloyd, HJ Finlay, W Vacarro, T Hyunh, A Kover…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 4 p. 1436 - 1439

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Citation Number: 38

Abstract

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... Steady-state volume of distribution was greater than total body water, indicating significant extravascular distribution. Terminal half-life was 0.57 h in rats. ...