Structure–activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1 (3H), 4′-piperidin-1-yl] propyl} pyrrolidine-2- …

…, A Rizzi, V Camarda, DG Lambert, J McDonald…

Index: Trapella, Claudio; Fischetti, Carmela; Pela', Michela; Lazzari, Ilaria; Guerrini, Remo; Calo', Girolamo; Rizzi, Anna; Camarda, Valeria; Lambert, David G.; McDonald, John; Regoli, Domenico; Salvadori, Severo Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 5080 - 5095

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Citation Number: 10

Abstract

Twelve derivatives of the nociceptin/orphanin FQ (N/OFQ) receptor (NOP) antagonist 1- benzyl-N-{3-[spiroisobenzofuran-1 (3H), 4′-piperidin-1-yl] propyl} pyrrolidine-2- carboxamide (Comp 24) were synthesized and tested in binding experiments performed on CHOhNOP cell membranes. Among them, a novel interesting NOP receptor antagonist (compound 35) was identified by blending chemical moieties taken from different NOP ...