L-Aspartic acid in acyclic stereoselective synthesis. Synthetic studies on amphotericin B
GJ McGarvey, JM Williams, RN Hiner…
Index: McGarvey; Williams; Hiner; et al. Journal of the American Chemical Society, 1986 , vol. 108, # 16 p. 4943 - 4952
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Citation Number: 136
Abstract
Abstract: The development of a potentially general approach to the synthesis of polyketide nature products is presented that features the use of L-aspartic acid as a synthetic equivalent to an asymmetric 1, 3-dicarbonyI fragment. Illustrations of the manner in which the rational application of covalent, chelation, and stereoelectronic control can be used to afford products of complementary stereochemistries are given. Thiol ester 9 has been ...
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