Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor

JA Campos-Sandoval, C Redondo…

Index: Campos-Sandoval, Jose Angel; Redondo, Clara; Kinsella, Gemma K.; Pal, Akos; Jones, Geraint; Eyre, Gwen S.; Hirst, Simon C.; Findlay, John B. C. Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4378 - 4387

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Citation Number: 9

Abstract

Serum retinol binding protein (sRBP) is released from the liver as a complex with transthyretin (TTR), a process under the control of dietary retinol. Elevated levels of sRBP may be involved in inhibiting cellular responses to insulin and in generating first insulin resistance and then type 2 diabetes, offering a new target for therapeutic attack for these conditions. A series of retinoid analogues were synthesized and examined for their ...