Arkivoc

Synthesis and biological evaluation of new indazole derivatives

…, G Daidone, MV Raimondi, MG Cusimano, G Bombieri…

Index: Plescia, Salvatore; Raffa, Demetrio; Plescia, Fabiana; Casula, Giovanni; Maggio, Benedetta; Daidone, Giuseppe; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Bombieri, Gabriella; Meneghetti, Fiorella Arkivoc, 2010 , vol. 2010, # 10 p. 163 - 177

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Citation Number: 4

Abstract

Abstract New N-methyl and N-ethyl substitutions in the indazole nucleus are reported by reacting 3-(2-aminobenzamido) indazole and the appropriate trimethyl/triethyl orthobenzoate. Single crystal X-ray analysis confirms the N-ethylation position for the 3-(1- ethyl-1H-indazol-3-yl)-2-phenylquinazolin-4 (3H)-one derivative 3f. Compounds 11a-d and 3a-d were tested to evaluate their antimicrobial, antiproliferative and COX inhibitory ...