Etiprednol dicloacetate, a new soft glucocorticoid drug candidate. Development of chemistry

A Csanádi, G Horváth, T Szekeres…

Index: Csanadi; Horvath; Szekeres; Hasko; Ila; Ivanics; Patthy; Salat; Seres; Pallagi; Toth; Szederkenyi; Konya; Tegdes; Bodor; Zubovics, Zoltan Pharmazie, 2004 , vol. 59, # 5 p. 349 - 359

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Citation Number: 3

Abstract

During development of chemistry of the soft drug candidate etiprednol dicloacetate (BNP- 166) 1) optimization studies on the three-step chemical synthesis resulted in a process that could be scaled-up to the kg level, 2) the impurity profile was determined, 3) synthetic routes were developed for the preparation of the radiolabeled target compound, and 4) a series of hydroxylated metabolites was prepared.