Synthesis of naphthyridone derivatives containing 8-alkoxyimino-1, 6-dizaspiro [3.4] octane scaffolds
…, S Wang, Y Chai, K Lv, GZ Shan, J Cao, SJ Li, HY Guo
Index: Feng, Lian-Shun; Liu, Ming-Liang; Wang, Shuo; Chai, Yun; Lv, Kai; Shan, Guang-Zhi; Cao, Jue; Li, Su-Jie; Guo, Hui-Yuan Tetrahedron, 2011 , vol. 67, # 43 p. 8264 - 8270
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Citation Number: 11
Abstract
The synthesis of naphthyridone derivatives containing 8-alkoxyimino-1, 6-dizaspiro [3.4] octane scaffolds, the position isomers of the side chain at the C-7 position of Zabofloxacin, has been achieved in eight steps from tert-butyl 3-cyano-4-oxopyrrolidine-1-carboxylate. The possible reaction mechanisms were also proposed. The key spirocyclic carbamate esters, which could be prepared using a modified Hofmann rearrangement strategy, were ...
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