Il Farmaco

Histamine H 1 receptor ligands: Part I. Novel thiazol-4-ylethanamine derivatives: synthesis and in vitro pharmacology

…, H Timmerman, OP Zuiderveld, MQ Zhang, R Glinka

Index: Walczynski; Timmerman; Zuiderveld; Zhang; Glinka Farmaco, 1999 , vol. 54, # 8 p. 533 - 541

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Citation Number: 22

Abstract

A series of 2-substituted thiazol-4-ylethanamines have been synthesized and tested for their histaminergic H1-receptor activities. The compounds with 2-phenyl substitution, regardless of the different physicochemical properties of the meta-substituents at the phenyl ring, showed weak H1-agonistic activity with pD2 values ranging from 4.35 to 5.36. When the phenyl group was replaced by a benzyl group, the resulting compounds all exhibited ...