Synthesis of chiral 1, 2-diamines
E Bruni, G Cardillo, M Orena, S Sandri, C Tomasini
Index: Bruni, Elena; Cardillo, Giuliana; Orena, Mario; Sandri, Sergio; Tomasini, Claudia Tetrahedron Letters, 1989 , vol. 30, # 13 p. 1679 - 1682
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Citation Number: 30
Abstract
Abstract (1′ S, 5R, S)-(1′-phenyleth-1′-yl)-5-iodomethyl-imidazolines 4a, b have been synthesised and easily resolved by silica gel chromatography. The correlation between the configuration and the 1 H NMR chemical shifts allows to assign the configuration at the C-5 of these intermediates. Each pure diastereomer has been converted to R (−)-and to S (+)-1, 2-propyldiamine, respectively.
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