Synthesis and Characterization of O, S-Dimethylphosphoramidothioate and N-Acetyl O, S-Dimethylphosphoramidothioate

S Ghadimi, SL Mousavi, Z Rahnama…

Index: Ghadimi; Mousavi; Rahnama; Rahimi Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 2 p. 347 - 354

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Citation Number: 8

Abstract

O, S-Dimethylphosphoramidothioate (methamidophos) and N-acetyl O, S-dimethylphos- phoramidothioate (acephate) were synthesized by new methods to investigate the structure– activity study of acetyl cholinesterase (AChE) inhibition through the parameters of log P, δ 31P, and IC50. After their characterization by NMR (31P, 31P {1H}, 13C, and 1H), IR, and mass spectroscopy, log P and δ 31P (31P chemical shift in NMR) were used to evaluate ...