Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy) propyl] cytosine (cidofovir) and related compounds

…, J Balzarini, E De Clercq, R Snoeck

Index: Goebel, R.; Richter, F.; Weichmann, H. Phosphorus, Sulfur and Silicon and the Related Elements, 1992 , vol. 73, # 1-4 p. 67 - 80

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Citation Number: 78

Abstract

... anhydride, DMF, rt, 4 days; (d) TsOCH 2 P(O)(OiPr) 2 , NaH, DMF, rt; (e) (CH 3 ) 3 SiBr, CH 3 CN, rt; (f) CH 3 ... a Conditions: (a) DMF, 120 °C, 3 h; (b) (CH 3 ) 3 SiBr, CH 3 CN, rt. ... However, in certain cases, an activity against DNA viruses was also observed with the (R)-isomers. ...