Organocatalyst-mediated enantioselective intramolecular Michael addition of aldehydes to vinyl sulfones

…, A Quintard, S Sulzer-Mossé, A Alexakis

Index: Bournaud, Chloee; Marchal, Estelle; Quintard, Adrien; Sulzer-Mosse, Sarah; Alexakis, Alexandre Tetrahedron Asymmetry, 2010 , vol. 21, # 13-14 p. 1666 - 1673

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Citation Number: 16

Abstract

During the last decade, asymmetric organocatalysis has gained considerable attention 1 and remarkable progress has been made since the pioneering reports of the proline intermolecular aldol reaction 2 and iminium ion catalysis concept. 3 For stereoselective C–C bond formation, Michael addition via enamine activation represents a very powerful method. 4 Moreover, different withdrawing groups on the Michael acceptors have been well ...