Synthesis and biological activity of N-substituted aminocarbonyl-1, 3-dioxolanes as VLA-4 antagonists
…, S Nair, VP Palle, S Dastidar, A Ray, MS Alam…
Index: Rehman, Abdul; Soni, Ajay; Naik, Keshav; Nair, Sreeji; Palle, Venkata P.; Dastidar, Sunanda; Ray, Abhijit; Alam; Salman, Mohammad; Cliffe, Ian A.; Sattigeri, Viswajanani Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5514 - 5520
Full Text: HTML
Citation Number: 5
Abstract
Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A novel set of compounds with a 1,3-dioxolane ring which acts as a proline bioisostere have been successfully designed as VLA-4 receptor antagonists. Compounds (18e), (28j), and (35g) were shown to have high receptor affinities. ... Pyrolidine ring in the N-acylphenylalanine class of VLA-4 ...
Related Articles:
[Chen, Ping; Cheng, Peter T. W.; Alam, Masud; Beyer, Barbara D.; Bisacchi, Gregory S.; Dejneka, Tamara; Evans, Adelaide J.; Greytok, Jill A.; Hermsmeier, Mark A.; Humphreys, W. Griffith; Jacobs, Glenn A.; Kocy, Octavian; Lin, Pin-Fang; Lis, Karen A.; Marella, Michael A.; Ryono, Denis E.; Sheaffer, Amy K.; Spergel, Steven H.; Sun, Chong-Qing; Tino, Joseph A.; Vite, Gregory; Colonno, Richard J.; Zahler, Robert; Barrish, Joel C. Journal of Medicinal Chemistry, 1996 , vol. 39, # 10 p. 1991 - 2007]
Designer Nanorings with Functional Cavities from Self??Assembling β??Sheet Peptides
[Park, Il-Soo; Yoon, You-Rim; Jung, Minseon; Kim, Kimoon; Park, Seongbyeong; Shin, Seokmin; Lim, Yong-Beom; Lee, Myongsoo Chemistry - An Asian Journal, 2011 , vol. 6, # 2 p. 452 - 458]
Total synthesis of (S, S)-isodityrosine
[Jung, Michael E.; Starkey, Laurie S. Tetrahedron, 1997 , vol. 53, # 26 p. 8815 - 8824]
[Gomez-Martinez, Paloma; Dessolin, Michele; Guibe, Francois; Albericio, Fernando Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2871 - 2874]
Preparation of phenylethylbenzamide derivatives as modulators of DNMT3 activity
[Kabro, Anzhelika; Lachance, Hugo; Marcoux-Archambault, Iris; Perrier, Valerie; Dore, Vicky; Gros, Christina; Masson, Veronique; Gregoire, Jean-Marc; Ausseil, Frederic; Cheishvili, David; Laulan, Nathalie Bibens; St-Pierre, Yves; Szyf, Moshe; Arimondo, Paola B.; Gagnon, Alexandre MedChemComm, 2013 , vol. 4, # 12 p. 1562 - 1570]