A facile one-pot preparation of isothiocyanates from aldoximes
JN Kim, KS Jung, HJ Lee, JS Son
Index: Kim, Jae Nyoung; Jung, Keum Shin; Lee, Hong Jung; Son, Ji Suk Tetrahedron Letters, 1997 , vol. 38, # 9 p. 1597 - 1598
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Citation Number: 42
Abstract
Isothiocyanates 2a-1 were prepared in excellent yields in a one-pot reaction from aldoxime derivatives 1a-1 by successive treatment of aldoxime with N-chlorosuccinimide (NCS), thiourea, and triethylamine. The use of HCl/DMF/Oxone system in the reaction instead of NCS was equally effective.
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