Preparation of benzolactams by Pd (OAc) 2-catalyzed direct aromatic carbonylation

K Orito, A Horibata, T Nakamura, H Ushito…

Index: Orito, Kazuhiko; Horibata, Akiyoshi; Nakamura, Takatoshi; Ushito, Harumi; Nagasaki, Hideo; Yuguchi, Motoki; Yamashita, Satoshi; Tokuda, Masao Journal of the American Chemical Society, 2004 , vol. 126, # 44 p. 14342 - 14343

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Citation Number: 204

Abstract

We developed a new method for Pd (II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd (OAc) 2 and Cu (OAc) 2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five-or six-membered benzolactams from secondary ω-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines.