Advanced Synthesis & Catalysis

Concise catalytic asymmetric total synthesis of biologically active tropane alkaloids

A Córdova, S Lin, A Tseggai

Index: Cordova, Armando; Lin, Shuangzheng; Tseggai, Abrehet Advanced Synthesis and Catalysis, 2012 ,  vol. 354,  # 7  p. 1363 - 1372

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Citation Number: 12

Abstract

Abstract A general strategy for the total asymmetric synthesis of valuable tropane alkaloids by catalytic stereoselective transformations is disclosed. The power of this approach is exemplified by the concise catalytic enantioselective total syntheses of (+)- methylecgonine,(−)-cocaine and (+)-cocaine as well as the first catalytic asymmetric total syntheses of a cocaine C-1 derivative and (+)-ferruginine starting from 5-oxo-protected-α, ...