Synthesis, renal vasodilator and dopamine??sensitive adenylate cyclase activities of O??Methyl derivatives of 6??chloro??2, 3, 4, 5??tetr ahydro??1??(4??hydroxyphenyl)??1H??3 …

ST Ross, RG Franz, JW Wilson…

Index: Ross; Franz; Wilson; et al. Journal of Heterocyclic Chemistry, 1986 ,  vol. 23,  # 6  p. 1805 - 1814

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Citation Number: 8

Abstract

Abstract The three possible mono-O-methyl derivatives of 6-chloro-2, 3, 4, 5-tetrahydro-1-(4- hydroxyphenyl)-1H-3-benzazepin-7, 8-diol (SK&F 82526)(1) have been synthesized to facilitate the isolation and characterization of metabolites of this compound and for biological testing. The syntheses generally involved preparation of appropriately substituted benzaldehydes, conversion of these to phenylacetic acids and use of these to N-acylate ...