Stereoselective total synthesis of the cembranolide diterpene anisomelic acid

JA Marshall, BS DeHoff

Index: Marshall, James A.; DeHoff, Bradley S. Tetrahedron Letters, 1986 ,  vol. 27,  # 40  p. 4873 - 4876

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Citation Number: 17

Abstract

The first total synthesis of (±)-anisomelic acid (I has been achieved via anti coupling of the allyl titanateIV (R 2 CH CHOCb, R 3 CH CH 2 , M Ti(O-i-Pr) 3 ) with aldehydeIII (R 1 =TBS) followed by (Z)-selective macrocyclization of the ester phosphateII (R OCb, Z PO(OMe) 2 ). ... Tetrahedron Lett., 24 (1983), p. 1687 Initial trials with the reported mercuric acetate-methanesulfonic acid hydrolysis method caused decomposition of carbamate9. ... We are indebted to Dr. ...