Efficient synthesis of lactosaminylated core-2 O-glycans

AK Misra, M Fukuda, O Hindsgaul

Index: Misra, Anup Kumar; Fukuda, Minoru; Hindsgaul, Ole Bioorganic and Medicinal Chemistry Letters, 2001 ,  vol. 11,  # 20  p. 2667 - 2669

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Citation Number: 13

Abstract

A series of lactosaminylated oligosaccharides found in mucin type O-glycans was synthesized using a generalized block strategy. The synthesis involved the addition of a protected lactosamine donor to a partially protected T-disaccharide derivative. The nonreducing galactose residues of the deblocked oligosaccharide products could be removed by β-galactosidase from jack bean to produce the corresponding GlcNAc ...