Cytochalasan synthesis: synthesis of an [11]-membered ring precursor of cytochalasin H

EJ Thomas, JWF Whitehead

Index: Thomas, Eric J.; Whitehead, John W. F. Journal of the Chemical Society, Chemical Communications, 1986 ,  # 9  p. 724 - 726

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Citation Number: 2

Abstract

The cytochalasin H precursor (20) has been synthesized using an intramolecular Diels-Alder reaction to control stereochemistry and to form the 1 I-membered ring. ... The cytochalasans,l an important group of biologically active fungal metabolites, have been the targets of much synthetic endeavour. To date total syntheses of the macrolide cyto- chalasan, cytochalasin B (1) ,2 and the [ 13]cytochalasan , proxiphomin (2) ,3 have been described, together with ...