The interaction between resistance modifiers such as pyrido [3, 2-g] quinoline, aza-oxafluorene and pregnane derivatives with DNA, plasmid DNA and tRNA

…, A Hilgeroth, S Gallo, A Mahamoud, J Barbe

Index: Sharples, Derek; Spengler, Gabriella; Molnar, Joseph; Antal, Zsuzsanna; Molnar, Annamaria; Kiss, Janos T.; Szabo, Jozsef A.; Hilgeroth, Andreas; Gallo, Sandrine; Mahamoud, Abdallah; Barbe, Jacques European Journal of Medicinal Chemistry, 2005 , vol. 40, # 2 p. 195 - 202

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Citation Number: 9

Abstract

Various resistance mechanisms such as complex formation with DNA, tRNA and MDR1 p- glycoprotein were modified in bacteria and cancer cells in presence of pregnane, pyridoquinoline, and aza-oxafluorene derivatives. Interaction between the compounds, plasmid DNA and tRNA was shown and compared to the interaction with calf thymus DNA. Complex formation with MDR1 p-glycoprotein and drug accumulation increased in cancer ...