A chemoenzymatic synthesis of leukotriene B4

CQ Han, D DiTullio, YF Wang…

Index: Han, Chao-Qi; DiTullio, Dennis; Wang, Yi-Fong; Sih, Charles J. Journal of Organic Chemistry, 1986 ,  vol. 51,  # 8  p. 1253 - 1258

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Citation Number: 43

Abstract

The dihydroxy acid leukotriene B4 (LTB4, 1) is biosynthesized from arachidonic acid via the 5-lipoxygenase pathway.'Studies on the biological properties of LTB4 have shown it to be one of the most potent chemotactic factors known for neutrophh2 The perceived importance of LTB, in allergic and inflammatory states3 and the difficulty in isolating LTB, in quantity from biological sources prompted several groups to embark on the synthesis of this compound. ...