Facile synthesis of mutagen X (MX): 3-chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one
V Velvadapu, ME McDonnell, EK Jaffe, AB Reitz
Index: Velvadapu, Venkata; McDonnell, Mark E.; Jaffe, Eileen K.; Reitz, Allen B. Tetrahedron Letters, 2012 , vol. 53, # 25 p. 3144 - 3146
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Abstract
3-Chloro-4-(dichloromethyl)-5-hydroxy-5H-furan-2-one (mutagen X, MX) was synthesized in six steps from commercially-available and inexpensive starting materials (27% overall yield). This synthesis enables the preparation of MX analogs and does not require the use of chlorine gas, as do previously reported methods.
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