Synlett

An enantioselective formal total synthesis of (-)-TAN1251A

JMA Auty, I Churcher, CJ Hayes

Index: Auty, James M. A.; Churcher, Ian; Hayes, Christopher J. Synlett, 2004 ,  # 8  p. 1443 - 1445

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Citation Number: 11

Abstract

Abstract An enantioselective total synthesis of the muscarinic inhibitor (-)-TAN1251A has been achieved. An alkylidene 1, 5-CH insertion reaction was used as a key step to produce a [5, 5]-spirocyclic intermediate, which was transformed into the [6, 5]-spirocyclic core of the natural product via an oxidative cleavage/aldol condensation sequence. The synthesis of the natural product was then completed using standard procedures.