Journal of organometallic chemistry

Optimization of asymmetric hydrogenation of 3-phenyl-3-butenoic acid catalyzed by rhodium (I)-4, 5-bis [(diphenylphosphino) methyl]-2, 2-dimethyldioxolane (DIOP)

K Yamamoto, K Ikeda, LK Yin

Index: Yamamoto, Keiji; Ikeda, Kiyoshi; Yin, Leong Kwai Journal of Organometallic Chemistry, 1989 ,  vol. 370, p. 319 - 332

Full Text: HTML

Citation Number: 3

Abstract

Abstract Enantioselective, homogeneous hydrogenation of 3-phenyl-3-butenoic acid (1) has extensively been examined in the presence of the rhodium (I)/4, 5-bis [(diphenylphosphino) methyl]-2, 2-dimethyldioxolane (DIOP) catalyst systems. Optimization of the reaction conditions was undertaken mainly by controlling effects of added tertiary amines as well as solvent polarities on the enantio-selectivity of the product. The best asymmetric yield (85.1 ...