General Ambient Temperature Benzylic Metalations Using Mixed-Metal Li/K-TMP Amide

A Manvar, P Fleming, DF O'Shea

Index: Blangetti, Marco; Fleming, Patricia; O'Shea, Donal F. Beilstein Journal of Organic Chemistry, 2011 ,  vol. 7, art. no. 145, p. 1249 - 1254

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Citation Number: 3

Abstract

Highly regioselective benzylic metalations in hydrocarbon solvent have been achieved at rt and 0° C using a mixed-metal Li/K-TMP amide comprised of KO t Bu, BuLi, and 2, 2, 6, 6,- tetramethylpiperidine (TMP (H)). Mixing of KO t Bu, BuLi, and TMP (H) in heptane gave a