Determination of the source of the N-methyl impurity in the synthesis of pemetrexed disodium heptahydrate

DP Kjell, DW Hallberg, JM Kalbfleisch…

Index: Organic Process Research and Development, , vol. 9, # 6 p. 738 - 742

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Citation Number: 13

Abstract

... Organic Process Research & ... A key portion of the development of a commercial synthesis is the identification of all impurities in the drug substance and later intermediates. ... The first method attempted was to examine all isolated process intermediates for an “M + 14” impurity. ...

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