Phytochemistry

The inhibition of glutamate dehydrogenase by derivatives of isophthalic acid

D Cunliffe, M Leason, D Parkin, PJ Lea

Index: Cunliffe, Denise; Leason, Mark; Parkin, Donald; Lea, Peter J. Phytochemistry (Elsevier), 1983 , vol. 22, # 6 p. 1357 - 1360

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Citation Number: 10

Abstract

Abstract A range of compounds, structurally related to glutamate, have been tested as inhibitors of pea leaf glutamate dehydrogenase assayed in either direction. Only 5-N- substituted derivatives of aminoisophthalic acid completely inhibited the enzyme when tested at concentrations equal to either those of 2-oxoglutarate or glutamate. A minimum of three carbon atoms attached linearly to the amino group was required for maximum ...