An alternate route to 2-amino-3-nitro-5-bromo-4-picoline: Regioselective pyridine synthesis via 2-nitramino-picoline intermediate

A Bhattacharya, VC Purohit, P Deshpande…

Index: Bhattacharya, Apurba; Purohit, Vikram C.; Deshpande, Prashant; Pullockaran, Annie; Grosso, John A.; DiMarco, John D.; Gougoutas, Jack Z. Organic Process Research and Development, 2007 , vol. 11, # 5 p. 885 - 888

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Citation Number: 4

Abstract

The 2-nitramino functionality in 2-nitramino-4-picoline was successfully exploited not only as a protecting group but also as a directional handle to afford an efficient, atom-economic, and regioselective synthesis of 2-amino-5-bromo-3-nitro-4-picoline (4), a precursor for a drug candidate in development.