Identification of Indoline-2-thione Analogs as Novel Potent Inhibitors of. ALPHA.-Melanocyte Stimulating Hormone Induced Melanogenesis

…, KC Lee, VK Sharma, N Sharma, E Roh, Y Kim…

Index: Thanigaimalai, Pillaiyar; Lee, Ki-Cheul; Sharma, Vinay Kumar; Sharma, Niti; Roh, Eunmiri; Kim, Youngsoo; Jung, Sang-Hun Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 10 p. 1285 - 1288

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Citation Number: 5

Abstract

Based on the hits, 3, 4-dihydroquinazoline-2-thione (1) and benzimidazole-2-thione (2), a series of indole-2-thione (3) and indole-2-thiol inhibitors (4) of melanogenesis were designed, synthesized and evaluated in melanoma B16 cells under the stimulant of α- melanocyte stimulating hormone (α-MSH). The indole-2-thione compounds (3a—g) exhibited an effective inhibitory activity on melanin synthesis. The Structure–Activity ...