Triarylpyridines: a versatile small molecule scaffold for G-quadruplex recognition

…, R Rodriguez, S Balasubramanian

Index: Waller, Zoe A. E.; Shirude, Pravin S.; Rodriguez, Raphael; Balasubramanian, Shankar Chemical Communications, 2008 , # 12 p. 1467 - 1469

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Citation Number: 41

Abstract

Quadruplex ligands have potential as anti-cancer agents 10 that act by interference with telomere maintenance 11 or by alteration of oncogene expression levels. 5,12 The modification of flat, aromatic molecules has led to G-quadruplex ligands that bind by a mode presumed to involve stacking with the terminal G-tetrad(s). 13 However, the G-tetrads are common to all quadruplexes, making discrimination between quadruplexes challenging. Given the ...