A Boron??Based Synthesis of the Natural Product (+)??trans??Dihydrolycoricidine

SL Poe, JP Morken

Index: Poe, Sarah L.; Morken, James P. Angewandte Chemie - International Edition, 2011 , vol. 50, # 18 p. 4189 - 4192

Full Text: HTML

Citation Number: 18

Abstract

Despite their potential for clinical use many of these compounds are found in low natural abundance; whereas narciclasine (1) is available in practical quantities,[1a, 3] the limited availability of lycoricidine (2), pancratistatin (3), and other derivatives poses one limitation to their development as viable therapeutic agents. Unsurprisingly, the limited availability of these isocarbostyrils, as well as their interesting frameworks, have made these attractive ...