Predictable and site-selective functionalization of poly (hetero) arene compounds by palladium catalysis
D Lapointe, T Markiewicz, CJ Whipp…
Index: Lapointe, David; Markiewicz, Thomas; Whipp, Christopher J.; Toderian, Amy; Fagnou, Keith Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 749 - 759
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Citation Number: 95
Abstract
The challenge of achieving selective and predictable functionalizations at C− H bonds with complex poly (hetero) aromatic substrates was addressed by two different approaches. Site- selectivity can be obtained by applying various reaction conditions that are (hetero) arene specific to substrates that contain indoles, pyridine N-oxide, and polyfluorinated benzenes. An experimental classification of electron-rich heteroarenes based on their reactivity ...
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