KF/Al2O3: Solid-Supported Reagent Used in 1, 3-Dipolar Cycloaddition Reaction of Nitrile Oxide
M Boruah, D Konwar
Index: Boruah, Monalisa; Konwar, Dilip Synthetic Communications, 2012 , vol. 42, # 22 p. 3261 - 3268
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Citation Number: 3
Abstract
The stereoselective synthesis of 2-isoxazolidine through 1,3-dipolar cycloaddition reaction of nitrile oxide, which is in situ generation from aldoxime in the presence of N-bromosuccinamide and solid-supported reagent KF/Al 2 O 3 at room temperature, is reported. KF/Al 2 O 3 is sufficiently basic such that it can replace organic bases such as Et 3 N used in typical procedures and it catalyses the reaction to enhance the rate of the reaction.
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