Scope and Applicability of an Expedient Synthesis Leading to Polysubstituted 3??(Carboxyphenyl) pyrroles

…, M Ghobrial, K Weigand, AL Marzinzik

Index: Ullrich, Thomas; Ghobrial, Michael; Weigand, Klaus; Marzinzik, Andreas L. Synthetic Communications, 2007 , vol. 37, # 7 p. 1109 - 1119

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Citation Number: 5

Abstract

Abstract A convenient three??step route toward a functionalized pyrrole building block for novel anti??inflammatory agents is reported. In contrast to previous strategies, the present approach focuses on inexpensive starting materials and application on a multigram scale. A high degree of functional diversity is demonstrated in various derivatives, and the scope and limitations of this route are discussed. Complementary to the described tetrasubstituted ...