Journal of medicinal chemistry

Mixed bifunctionality. III. Antitumor activity of sesame oil solutions of simple alkylating derivatives of polynuclear hydrocarbons

RM Peck, AP O'Connell

Index: Peck,R.M.; O'Connell,A.P. Journal of Medicinal Chemistry, 1970 , vol. 13, p. 919 - 922

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Citation Number: 5

Abstract

We have previously reported the discovery that antitumor activity is conferred on a monofunctional PI; on S half m~ stard,~ and on a simpler alkylating function5 by the presence of a polynuclear moiety in the same molecule. Several simple chloromethyl aromatic hydrocarbons were among the most potent compounds. This discovery was surprising since these are hydrophobic, insoluble chemicals which were given as fine ...