Palladium-nanoparticle-catalyzed 1, 7-palladium migration involving C–H activation, followed by intramolecular amination: regioselective synthesis of N 1- …

…, M Al-Amin, N Hoshiya, J Wouters…

Index: Al-Amin, Mohammad; Arai, Satoshi; Hoshiya, Naoyoki; Honma, Tetsuo; Tamenori, Yusuke; Sato, Takatoshi; Yokoyama, Mami; Ishii, Akira; Takeuchi, Masashi; Maruko, Tomohiro; Shuto, Satoshi; Arisawa, Mitsuhiro Journal of Organic Chemistry, 2013 , vol. 78, # 15 p. 7575 - 7581

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Citation Number: 17

Abstract

A sulfur-modified gold-supported palladium material (SAPd) has been developed bearing palladium nanoparticles on its surface. Herein, we report for the first time the use of SAPd to affect a Pd-nanoparticle-catalyzed 1, 7-Pd migration reaction for the synthesis of benzotriazoles via C–H bond activation. The resulting benzotriazoles were evaluated in terms of their inhibitory activity toward indoleamine 2, 3-dioxygenase.