9-Benzylpurines with inhibitory activity against Mycobacterium tuberculosis

AK Bakkestuen, LL Gundersen, G Langli, F Liu…

Index: Bakkestuen, Anne Kristin; Gundersen, Lise-Lotte; Langli, Geir; Liu, Fusheng; Nolsoe, Jens M.J. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1207 - 1210

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Citation Number: 143

Abstract

9-Benzylpurines with a variety of substituents in the 2-, 6-and/or 8-position have been prepared and screened for antimycobacterial effects. High inhibitory activity against Mycobacterium tuberculosis was found for 9-benzylpurines carrying a phenylethynyl-, trans- styryl or aryl substituents in the 6-position and generally chlorine in the 2-position tends to increase activity.